CHILDHOOD CANCER REPOSITORY

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Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell LinePhase of Therapy Sample TypeMYCNALKTMMTp53p53pO2  
        2%5%20%
SK-N-FIPD NWTALTM246RNF  ✓
CHLA-90PDbone marrowNF1245VALTE286KNF  ✓
COG-N-512 PDbone marrow210 ALTWT ✓✓✓
COG-N-515PDbone marrow183 ALTWT ✓✓✓
COG-N-569hnbDxbone marrow  ALTWT  ✓ 
COG-N-700Dxtumor  ALT  ✓✓✓
LA-N-6PDbone marrowND1091NEST F  ✓
CHLA-132PDbone marrowN EST    ✓
COG-N-291PDbone marrow3WTEST    ✓
COG-N-323Dxtumor2WTEST    ✓
COG-N-325PDtumorAWTEST    ✓
COG-N-387hPD 152WTEST   ✓ 
COG-N-442hDxleft bone marrow2WTEST   ✓ 
COG-N-509hnbDxbone marrow2 EST   ✓ 
COG-N-518Dxbone marrow4 EST NF✓✓✓
COG-N-562hnbDxtumorN EST  ✓✓✓
NB-EBc1PD NWT     ✓
SMS-KANDxsolid tumorAWT  F  ✓
SMS-KANRPDbone marrowAWT  F  ✓
SMS-MSNDxbone marrow       ✓
CHLA-8PDtumorAWT  F  ✓
CHLA-21PDbone marrowA      ✓
CHLA-22PDbone marrowN      ✓
CHLA-27Dxbone marrowAF1174L     ✓
CHLA-28PDbone marrowAF1245C     ✓
CHLA-34PDbone marrowN      ✓
CHLA-35Dxbone marrow       ✓
CHLA-41PDtumorAWT     ✓
CHLA-43Dxbone marrow WT     ✓
CHLA-46PDtumorAWT     ✓
CHLA-51PDbone marrowNWT  F  ✓
CHLA-54Dx A      ✓
CHLA-58PDtumor       ✓
CHLA-70PDbone marrowN      ✓
CHLA-72PDperipheral bloodA      ✓
CHLA-78Dxbone marrow       ✓
CHLA-81PDtumorA      ✓
CHLA-83Dxbone marrow       ✓
CHLA-84Dxtumor       ✓
CHLA-89Dxtumor       ✓
CHLA-95PDtumorAR1275Q     ✓
CHLA-100Dxtumor       ✓
CHLA-101Dxbone marrow       ✓
CHLA-102PDtumorA      ✓
CHLA-103PDtumor       ✓
CHLA-105Dxbone marrow       ✓
CHLA-108PDbone marrowA      ✓
CHLA-110PDbone marrowA      ✓
CHLA-123Dxperipheral bloodA      ✓
CHLA-125PDbone marrowA      ✓
CHLA-126Dxbone marrow       ✓
CHLA-127PDtumor       ✓
CHLA-134PDbone marrowAWT  NF  ✓
CHLA-137Dxtumor       ✓
CHLA-138Dxbone marrow       ✓
CHLA-140PDbone marrowNWT     ✓
CHLA-142Dxbone marrow       ✓
CHLA-146PDbone marrowN      ✓
CHLA-150PDbone marrowNR1275Q     ✓
CHLA-151DxtumorAR1275Q     ✓
CHLA-160Dxtumor       ✓
CHLA-161PDbone marrow       ✓
CHLA-183PDbone marrowN      ✓
CHLA-188LPDbone marrowAWT     ✓
CHLA-188RPDbone marrowAWT     ✓
CHLA-189PDperipheral blood       ✓
CHLA-232PD A      ✓
CHLA-253PDtumorAWT     ✓
COG-N-272Dxsolid tumor       ✓
COG-N-284PDliver metastasis       ✓
COG-N-296Dxbone marrowA      ✓
COG-N-302Dxsolid tumor       ✓
COG-N-475hPDtumor119R1275Q    ✓✓
COG-N-496Dxbone marrow74WT   ✓✓✓
COG-N-503hDxbone marrowN     ✓ 
COG-N-504Dxbone marrowN     ✓✓
COG-N-507hPDbone marrow97     ✓ 
COG-N-508hPDbone marrowA     ✓ 
COG-N-513PDbone marrowA    ✓✓✓
COG-N-514PDbone marrowA    ✓✓ 
COG-N-521Dxbone marrow     ✓✓✓
COG-N-522hDxbone marrow      ✓ 
COG-N-523hDxbone marrow      ✓ 
COG-N-524hDxbone marrow      ✓ 
COG-N-527hDxbone marrow     ✓✓ 
COG-N-531hDxbone marrowA     ✓ 
COG-N-532Dxbone marrowN    ✓✓✓
COG-N-539DxtumorA    ✓✓✓
COG-N-542hDxbone marrowA     ✓ 
COG-N-543hDxbone marrowA    ✓✓ 
COG-N-544Dxbone marrow     ✓✓✓
COG-N-546hDxbone marrowA    ✓✓ 
COG-N-548Dxbone marrowN    ✓✓✓
COG-N-549PDtumorNF1174L   ✓✓✓
COG-N-550hDxbone marrowA    ✓✓ 
COG-N-552hDXbone marrowA    ✓✓ 
COG-N-554Dxbone marrowA    ✓✓✓
COG-N-555hDxbone marrow      ✓ 
COG-N-556Dxbone marrowA    ✓✓✓
COG-N-558hDxtumorA    ✓✓ 
COG-N-563Dxbone marrowA    ✓✓✓
COG-N-565PDright bone marrowN    ✓✓✓
COG-N-566DxbloodN    ✓✓✓
COG-N-570hDxbloodA    ✓✓ 
COG-N-571Dxbone marrowN     ✓✓
COG-N-572hDxbone marrowN     ✓ 
COG-N-574Dxbone marrowA    ✓✓✓
COG-N-575Dxbone marrowA    ✓✓✓
COG-N-576h2PDbone marrow     ✓  
COG-N-577PD-PMblood     ✓✓✓
COG-N-578PDbone marrowN    ✓✓✓
COG-N-579hPDbone marrowN    ✓✓ 
COG-N-581hDxbone marrowA    ✓✓ 
COG-N-582hDxbone marrowA    ✓✓ 
COG-N-585Dxbone marrowA    ✓✓✓
COG-N-586Dxbone marrowA    ✓✓✓
COG-N-587hDxbone marrowN    ✓✓✓
COG-N-591Dxbone marrowA    ✓✓✓
COG-N-592Dxbone marrowA    ✓✓✓
COG-N-596hPDtumorA    ✓✓ 
COG-N-597hDxbone marrowN    ✓✓ 
COG-N-598h2Dxbone marrowN    ✓✓ 
COG-N-599PDbone marrowA    ✓✓✓
COG-N-600Dxbone marrowA    ✓✓✓
COG-N-601h2Dxbone marrowA    ✓✓ 
COG-N-602Dxbone marrow     ✓✓✓
COG-N-614Dxbone marrow     ✓✓✓
COG-N-616hDxbone marrowN     ✓ 
COG-N-617hDxbone marrow     ✓✓ 
COG-N-618PDbone marrowNWT   ✓✓✓
COG-N-619PDbone marrowNWT   ✓✓✓
COG-N-621hPDbone marrow     ✓✓ 
COG-N-623PDtumorAWT   ✓✓✓
COG-N-626hDxbone marrow      ✓ 
COG-N-627hDxtumorA    ✓✓✓
COG-N-628Dxbone marrowAWT   ✓✓✓
COG-N-629Dxbone marrow     ✓✓✓
COG-N-632hPDbone marrow      ✓ 
COG-N-633PDbone marrow     ✓✓✓
COG-N-635hDxbone marrow     ✓✓ 
COG-N-636DxtumorAWT   ✓✓✓
COG-N-637Dxbone marrow     ✓✓✓
COG-N-638hDxbone marrow     ✓✓ 
COG-N-639hDxbone marrow     ✓✓ 
COG-N-640hDxbone marrow     ✓✓ 
COG-N-645PD-PMblood       ✓
COG-N-646Dxbone marrow     ✓✓✓
COG-N-647Dxbone marrow     ✓✓✓
COG-N-652h2Dxbone marrowN       
COG-N-654hDxbone marrow      ✓ 
COG-N-660hnbPD-PMbloodN     ✓ 
COG-N-662hDxbone marrow      ✓ 
COG-N-663h2Dxbone marrow     ✓  
COG-N-667hDxbone marrow      ✓ 
COG-N-671hDxbone marrow      ✓ 
COG-N-672PD-PMblood     ✓✓✓
COG-N-675 Dxbone marrow     ✓✓✓
COG-N-677hnbPDbone marrow      ✓ 
COG-N-678hPDbone marrow      ✓ 
COG-N-679Dxbone marrow     ✓✓✓
COG-N-680PDbone marrow     ✓ ✓
COG-N-683Dxbone marrow     ✓✓✓
COG-N-685PD-PMblood     ✓✓✓
COG-N-696hDxbone marrow      ✓ 
COG-N-697hDxtumor     ✓✓ 
COG-N-698Dxtumor      ✓✓
COG-N-701Dxbone marrow      ✓✓

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

2 -MYCN oncogene amplification
N: MYCN Non-Amplified
A: MYCN Amplified

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

ALK mutation

WT: Wild Type

TMM:Telomere Maintenance mechanism

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive