CHILDHOOD CANCER REPOSITORY

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Brain

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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Request Cell LinePhase of DiseaseSample TypeAge (years)DiagnosispO2
      2% O25% O220%O2
CHLA-198Dxtumor Anaplastic Astrocytoma--✓
CHLA-259Dxposterior fossa14Anaplastic Medulloblastoma--✓
COG-G-407Dxtumor Anaplastic Oligodendroglioma-✓✓
BT-12Dxtumor0.2Atypical Teratoid Rhabdoid Tumor--✓
CHLA-135Dxtumor Atypical Teratoid Rhabdoid Tumor---
CHLA-266Dxposterior fossa1.5Atypical Teratoid Rhabdoid Tumor---
COG-AR-359Dxtumor Atypical Teratoid Rhabdoid Tumor-✓✓
COG-AR-397hnbPDcerebrospinal fluid Atypical Teratoid Rhabdoid Tumor-✓-
CHLA-148Dxbone marrow DNET--✓
COG-B-277PD  DNET--✓
SJ-GBM2PDbrain tumor5Glioblastoma Multiforme   
CHLA-200PD-PMparietal lobe12Glioblastoma Multiforme--✓
CHLA-260PDtumor Glioblastoma Multiforme--✓

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive