CHILDHOOD CANCER REPOSITORY

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Neuroblastoma Cell Lines Established at Diagnosis (pretherapy)

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell LinePhase of Therapy Sample TypeMYCN*ALKTMMTp53p53pO2  
        2%5%20%
LA-N-5Dxbone marrowAR1275QTERT +    ✓
NB-1643Dx AR1275QTERT +    ✓
SK-N-BE(1)Dx AWTTERT +WTF  ✓
SMS-KANDxsolid tumorAWT  F  ✓
SMS-KCNDxsolid tumorAR1275QTERT + F  ✓
SMS-MSNDxbone marrow       ✓
SMS-SANDxbone marrowAF1174LTERT + F  ✓
CHLA-14Dx A TERT +    ✓
CHLA-15DxtumorNR1275QTERT + F  ✓
CHLA-16Dxpleural fluidNR1275QTERT +    ✓
CHLA-27Dxbone marrowAF1174L     ✓
CHLA-29Dxbone marrowAWTTERT +    ✓
CHLA-30DxtumorA TERT +    ✓
CHLA-35Dxbone marrow       ✓
CHLA-42Dxbone marrowNR1275QTERT + F  ✓
CHLA-43Dxbone marrow WT     ✓
CHLA-44Dxbone marrow  TERT +    ✓
CHLA-54Dx A      ✓
CHLA-78Dxbone marrow       ✓
CHLA-83Dxbone marrow       ✓
CHLA-84Dxtumor       ✓
CHLA-89Dxtumor       ✓
CHLA-100Dxtumor       ✓
CHLA-101Dxbone marrow       ✓
CHLA-105Dxbone marrow       ✓
CHLA-122Dxbone marrowAWTTERT + F  ✓
CHLA-123Dxperipheral bloodA      ✓
CHLA-126Dxbone marrow       ✓
CHLA-137Dxtumor       ✓
CHLA-138Dxbone marrow       ✓
CHLA-142Dxbone marrow       ✓
CHLA-144Dxbone marrowAWTTERT +    ✓
CHLA-151DxtumorAR1275Q     ✓
CHLA-160Dxtumor       ✓
COG-N-261Dxtumor34WTTERT +    ✓
COG-N-263Dxtumor48WTTERT +    ✓
COG-N-265Dxtumor123WTTERT +    ✓
COG-N-272Dxsolid tumor       ✓
COG-N-276Dxbone marrowAWTTERT +    ✓
COG-N-278Dxsolid tumor26WTTERT +    ✓
COG-N-282Dxsolid tumorA TERT +    ✓
COG-N-283Dxsolid tumor88 TERT +    ✓
COG-N-290Dxsolid tumor  TERT +    ✓
COG-N-293Dxsolid tumor56WTTERT +    ✓
COG-N-294Dxsolid tumor42R1275QTERT + NF  ✓
COG-N-295Dxsolid tumor2F1174LTERT +    ✓
COG-N-296Dxbone marrowA      ✓
COG-N-297Dxsolid tumor24WTTERT +    ✓
COG-N-298Dxsolid tumor11R1275QTERT +    ✓
COG-N-299Dxsolid tumor193WTTERT +    ✓
COG-N-302Dxsolid tumor       ✓
COG-N-303Dxsolid tumorAWTTERT +    ✓
COG-N-305Dxsolid tumorAWTTERT +    ✓
COG-N-312Dxbone marrow62 TERT +    ✓
COG-N-316Dxbone marrow2 TERT +    ✓
COG-N-322Dxsolid tumor323WTTERT +    ✓
COG-N-323Dxtumor2WTEST    ✓
COG-N-324Dxbone marrow61WTTERT +    ✓
COG-N-328hDxtumor130WTTERT +   ✓ 
COG-N-331Dxbone marrow85WTTERT +    ✓
COG-N-333Dxbone marrow144F1174LTERT +    ✓
COG-N-347Dxbone marrow248WTTERT +    ✓
COG-N-349Dxbone marrow90WTTERT +   ✓✓
COG-N-353Dxbone marrow38WTTERT +   ✓✓
COG-N-35Dxbone marrow66 TERT +   ✓✓
COG-N-367Dxbone marrow22R1275QTERT +   ✓✓
COG-N-373Dxbone marrow78WTTERT +    ✓
COG-N-442hDxleft bone marrow2WTEST   ✓ 
COG-N-445Dxbone marrow117WTTERT +  ✓✓✓
COG-N-462hDxright bone marrowAWTTERT +  ✓  
COG-N-463h2Dxleft bone marrow277WTTERT +  ✓✓ 
COG-N-474Dxbone marrow338F1174LTERT +   ✓ 
COG-N-480h2Dxright bone marrow42WTTERT +   ✓ 
COG-N-485hDxbone marrow36 TERT +  ✓✓ 
COG-N-490hDxbone marrowAWTTERT +  ✓✓ 
COG-N-491hDxperipheral blood370WTTERT +   ✓ 
COG-N-496Dxbone marrow74WT   ✓✓✓
COG-N-497Dxbone marrow40 TERT +  ✓✓✓
COG-N-500Dxbone marrowN TERT +   ✓✓
COG-N-503hDxbone marrowN     ✓ 
COG-N-504Dxbone marrowN     ✓✓
COG-N-509hnbDxbone marrow2 EST   ✓ 
COG-N-518Dxbone marrow4 EST NF✓✓✓
COG-N-521Dxbone marrow     ✓✓✓
COG-N-522hDxbone marrow      ✓ 
COG-N-523hDxbone marrow      ✓ 
COG-N-524hDxbone marrow      ✓ 
COG-N-527hDxbone marrow     ✓✓ 
COG-N-531hDxbone marrowA     ✓ 
COG-N-532Dxbone marrowN    ✓✓✓
COG-N-539DxtumorA    ✓✓✓
COG-N-540Dxbone marrowN TERT +  ✓✓✓
COG-N-542hDxbone marrowA     ✓ 
COG-N-543hDxbone marrowA    ✓✓ 
COG-N-544Dxbone marrow     ✓✓✓
COG-N-546hDxbone marrowA    ✓✓ 
COG-N-548Dxbone marrowN    ✓✓✓
COG-N-550hDxbone marrowA    ✓✓ 
COG-N-552hDXbone marrowA    ✓✓ 
COG-N-554Dxbone marrowA    ✓✓✓
COG-N-555hDxbone marrow      ✓ 
COG-N-556Dxbone marrowA    ✓✓✓
COG-N-557Dxbone marrowAF1245LTERT +  ✓✓✓
COG-N-558hDxtumorA    ✓✓ 
COG-N-562hnbDxtumorN EST  ✓✓✓
COG-N-563Dxbone marrowA    ✓✓✓
COG-N-566DxbloodN    ✓✓✓
COG-N-569hnbDxbone marrow  ALTWT  ✓ 
COG-N-570hDxbloodA    ✓✓ 
COG-N-571Dxbone marrowN     ✓✓
COG-N-572hDxbone marrowN     ✓ 
COG-N-573Dxbone marrowAWTTERT +  ✓✓✓
COG-N-574Dxbone marrowA    ✓✓✓
COG-N-575Dxbone marrowA    ✓✓✓
COG-N-581hDxbone marrowA    ✓✓ 
COG-N-582hDxbone marrowA    ✓✓ 
COG-N-585Dxbone marrowA    ✓✓✓
COG-N-586Dxbone marrowA    ✓✓✓
COG-N-587hDxbone marrowN    ✓✓✓
COG-N-590DxtumorAWTTERT +  ✓✓✓
COG-N-591Dxbone marrowA    ✓✓✓
COG-N-592Dxbone marrowA    ✓✓✓
COG-N-597hDxbone marrowN    ✓✓ 
COG-N-598h2Dxbone marrowN    ✓✓ 
COG-N-600Dxbone marrowA    ✓✓✓
COG-N-601h2Dxbone marrowA    ✓✓ 
COG-N-602Dxbone marrow     ✓✓✓
COG-N-603DxtumorAWTTERT +  ✓✓✓
COG-N-614Dxbone marrow     ✓✓✓
COG-N-616hDxbone marrowN     ✓ 
COG-N-617hDxbone marrow     ✓✓ 
COG-N-626hDxbone marrow      ✓ 
COG-N-627hDxtumorA    ✓✓✓
COG-N-628Dxbone marrowAWT   ✓✓✓
COG-N-629Dxbone marrow     ✓✓✓
COG-N-635hDxbone marrow     ✓✓ 
COG-N-636DxtumorAWT   ✓✓✓
COG-N-637Dxbone marrow     ✓✓✓
COG-N-638hDxbone marrow     ✓✓ 
COG-N-639hDxbone marrow     ✓✓ 
COG-N-640hDxbone marrow     ✓✓ 
COG-N-646Dxbone marrow     ✓✓✓
COG-N-647Dxbone marrow     ✓✓✓
COG-N-651h2Dxbone marrowN TERT +  ✓  
COG-N-652h2Dxbone marrowN       
COG-N-654hDxbone marrow      ✓ 
COG-N-662hDxbone marrow      ✓ 
COG-N-663h2Dxbone marrow     ✓  
COG-N-667hDxbone marrow      ✓ 
COG-N-671hDxbone marrow      ✓ 
COG-N-675 Dxbone marrow     ✓✓✓
COG-N-679Dxbone marrow     ✓✓✓
COG-N-682/td>Dxbone marrow  TERT +  ✓✓✓
COG-N-683Dxbone marrow     ✓✓✓
COG-N-696hDxbone marrow      ✓ 
COG-N-697hDxtumor     ✓✓ 
COG-N-698Dxtumor      ✓✓
COG-N-700Dxtumor  ALT  ✓✓✓
COG-N-701Dxbone marrow      ✓✓

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

2 -MYCN oncogene amplification
N: MYCN Non-Amplified
A: MYCN Amplified

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

ALK mutation

WT: Wild Type

TMM:Telomere Maintenance mechanism

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive