CHILDHOOD CANCER REPOSITORY

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MYCN Amplified

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell LinePhase of Therapy Sample TypeMYCN*ALKTMMTp53p53pO2  
         2%5%20%
COG-N-261Dxtumor34WTTERT +    ✓
COG-N-263Dxtumor48WTTERT +    ✓
COG-N-265Dxtumor123WTTERT +    ✓
COG-N-276Dxbone marrowAWTTERT +    ✓
COG-N-278Dxsolid tumor26WTTERT +    ✓
COG-N-282Dxsolid tumorA TERT +    ✓
COG-N-283Dxsolid tumor88 TERT +    ✓
COG-N-289PDsolid tumor160WTTERT +    ✓
COG-N-293Dxsolid tumor56WTTERT +    ✓
COG-N-294Dxsolid tumor42R1275QTERT + NF  ✓
COG-N-296Dxbone marrowA      ✓
COG-N-297Dxsolid tumor24WTTERT +    ✓
COG-N-299Dxsolid tumor193WTTERT +    ✓
COG-N-303Dxsolid tumor52WTTERT +    ✓
COG-N-305Dxsolid tumor133WTTERT +    ✓
COG-N-312Dxbone marrow62 TERT +    ✓
COG-N-318PDsolid tumor400WTTERT +    ✓
COG-N-321PDbone marrow29 TERT + NF  ✓
COG-N-322Dxsolid tumor323WTTERT +    ✓
COG-N-324Dxbone marrow61WTTERT +    ✓
COG-N-325PDtumorAWTEST    ✓
COG-N-327PDbone marrow300WTTERT +   ✓✓
COG-N-328hDxtumor130WTTERT +   ✓ 
COG-N-331Dxbone marrow85WTTERT +    ✓
COG-N-333Dxbone marrow144F1174LTERT +    ✓
COG-N-334PDbone marrow30WTTERT +   ✓✓
COG-N-347Dxbone marrow248WTTERT +    ✓
COG-N-349Dxbone marrow90WTTERT +   ✓✓
COG-N-353Dxbone marrow38WTTERT +   ✓✓
COG-N-354Dxbone marrow66 TERT +   ✓✓
COG-N-367Dxbone marrow22R1275QTERT +   ✓✓
COG-N-373Dxbone marrow78WTTERT +    ✓
COG-N-387hPD 152WTEST   ✓ 
COG-N-399PD-PMblood50WTTERT + F ✓✓
COG-N-415PD-PMblood400F1174LTERT +   ✓✓
COG-N-421PD-PMblood34WTTERT + NF   
COG-N-440PD-PMblood250WTTERT + F ✓ 
COG-N-445Dxbone marrow117WTTERT +  ✓✓✓
COG-N-452PD-PMblood62F1174LTERT + F✓✓✓
COG-N-453PD-PMtumor318WTTERT + F✓✓ 
COG-N-462hDxright bone marrowAWTTERT +  ✓  
COG-N-463h2Dxleft bone marrow277WTTERT +  ✓✓ 
COG-N-471PD-PMblood360WTTERT + NF ✓ 
COG-N-473hPDbone marrow150WTTERT +  ✓✓✓
COG-N-474Dxbone marrow338F1174LTERT +   ✓ 
COG-N-475hPDtumor119R1275Q    ✓✓
COG-N-480h2Dxright bone marrow42WTTERT +   ✓ 
COG-N-482hPDbone marrowA TERT +  ✓✓ 
COG-N-485hDxbone marrow36 TERT +  ✓✓ 
COG-N-490hDxbone marrow208WTTERT +  ✓✓ 
COG-N-491hDxperipheral blood370WTTERT +   ✓ 
COG-N-496Dxbone marrow74WT   ✓✓✓
COG-N-497Dxbone marrow40 TERT +  ✓✓✓
COG-N-505PD-PMblood96WTTERT + F✓✓✓
COG-N-507hPDbone marrow97     ✓ 
COG-N-508hPDbone marrow44     ✓ 
COG-N-512 PDbone marrow210 ALTWT ✓✓✓
COG-N-513PDbone marrow132    ✓✓✓
COG-N-514PDbone marrow324    ✓✓ 
COG-N-515PDbone marrow183 ALTWT ✓✓✓
COG-N-519PD-PMblood106WTTERT + NF✓✓✓
COG-N-522hDxbone marrow252     ✓ 
COG-N-531hDxbone marrowA     ✓ 
COG-N-536hPD-PMblood165R1275QTERT + NF✓✓ 
COG-N-539Dxtumor87    ✓✓✓
COG-N-542hDxbone marrow134     ✓ 
COG-N-543hDxbone marrow392    ✓✓ 
COG-N-546hDxbone marrowA    ✓✓ 
COG-N-550hDxbone marrow165    ✓✓ 
COG-N-552hDXbone marrow172    ✓✓ 
COG-N-553PDbone marrow175 TERT +  ✓✓✓
COG-N-554Dxbone marrow59    ✓✓✓
COG-N-555hDxbone marrow250     ✓ 
COG-N-556Dxbone marrowA    ✓✓✓
COG-N-556Dxbone marrowA    ✓✓✓
COG-N-557Dxbone marrowAF1245LTERT +  ✓✓✓
COG-N-558hDxtumorA    ✓✓ 
COG-N-561PD-PMbloodA F1245ITERT + F✓✓✓
COG-N-563Dxbone marrowA    ✓✓✓
COG-N-564hPD-PMbloodA TERT +  ✓✓ 
COG-N-570hDxbloodA    ✓✓ 
COG-N-573Dxbone marrowAWTTERT +  ✓✓✓
COG-N-574Dxbone marrowA    ✓✓✓
COG-N-575Dxbone marrowA    ✓✓✓
COG-N-581hDxbone marrowA    ✓✓ 
COG-N-582hDxbone marrowA    ✓✓ 
COG-N-585Dxbone marrowA    ✓✓✓
COG-N-586Dxbone marrowA    ✓✓✓
COG-N-590DxtumorAWTTERT +  ✓✓✓
COG-N-591Dxbone marrowA    ✓✓✓
COG-N-592Dxbone marrowA    ✓✓✓
COG-N-596hPDtumorA    ✓✓ 
COG-N-599PDbone marrowA    ✓✓✓
COG-N-600Dxbone marrowA    ✓✓✓
COG-N-601h2Dxbone marrowA    ✓✓ 
COG-N-603DxtumorAWTTERT +  ✓✓✓
COG-N-623PDtumorAWT   ✓✓✓
COG-N-627hDxtumorA    ✓✓✓
COG-N-628Dxbone marrowAWT   ✓✓✓
COG-N-636DxtumorAWT   ✓✓✓
LA-N-5Dxbone marrowAR1275QTERT +    ✓
NB-1643Dx AR1275QTERT +    ✓
SK-N-BE(1)Dx AWTTERT +WTF  ✓
SK-N-BE(2)PD AWTTERT +C135FNF  ✓
SMS-KANDxsolid tumorAWT  F  ✓
SMS-KANRPDbone marrowAWT  F  ✓
SMS-KCNDxsolid tumorAR1275QTERT + F  ✓
SMS-KCNRPDbone marrowAF1174LTERT + F  ✓
SMS-SANDxbone marrowAF1174LTERT + F  ✓
CHLA-8PDtumorAWT  F  ✓
CHLA-11PD-PMperipheral bloodAWTTERT + NF  ✓
CHLA-12PD-PMbone marrowAWTTERT + NF  ✓
CHLA-14Dx A TERT +    ✓
CHLA-21PDbone marrowA      ✓
CHLA-24PDpleural fluidAWTTERT +    ✓
CHLA-27Dxbone marrowAF1174L     ✓
CHLA-28PDbone marrowAF1245C     ✓
CHLA-29Dxbone marrowAWTTERT +    ✓
CHLA-30DxtumorA TERT +    ✓
CHLA-41PDtumorAWT     ✓
CHLA-46PDtumorAWT     ✓
CHLA-52PD-PMbone marrowAF1174LTERT + NF  ✓
CHLA-53PD-PMperipheral bloodAF1174LTERT + NF  ✓
CHLA-54Dx A      ✓
CHLA-72PDperipheral bloodA      ✓
CHLA-81PDtumorA      ✓
CHLA-95PDtumorAR1275Q     ✓
CHLA-102PDtumorA      ✓
CHLA-108PDbone marrowA      ✓
CHLA-110PDbone marrowA      ✓
CHLA-119PDbone marrowAWTTERT + NF  ✓
CHLA-122Dxbone marrowAWTTERT + F  ✓
CHLA-123Dxperipheral bloodA      ✓
CHLA-125PDbone marrowA      ✓
CHLA-134PDbone marrowAWT  NF  ✓
CHLA-136PDperipheral bloodAWTTERT +WTF  ✓
CHLA-144Dxbone marrowAWTTERT +    ✓
CHLA-145PDbone marrowAWTTERT +    ✓
CHLA-151DxtumorAR1275Q     ✓
CHLA-188LPDbone marrowAWT     ✓
CHLA-188RPDbone marrowAWT     ✓
CHLA-225PD-PMpleural fluidAWTTERT + NF  ✓
CHLA-232PD A      ✓
CHLA-247PDbone marrowAWTTERT +    ✓
CHLA-253PDtumorAWT     ✓
LA-N-5Dxbone marrowAR1275QTERT +    ✓
NB-1643Dx AR1275QTERT +    ✓
SK-N-BE(1)Dx AWTTERT +WTF  ✓
SK-N-BE(2)PD AWTTERT +C135FNF  ✓
SMS-KANDxsolid tumorAWT  F  ✓
SMS-KANRPDbone marrowAWT  F  ✓
SMS-KCNDxsolid tumorAR1275QTERT + F  ✓
SMS-KCNRPDbone marrowAF1174LTERT + F  ✓
SMS-SANDxbone marrowAF1174LTERT + F  ✓

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

2 -MYCN oncogene amplification
N: MYCN Non-Amplified
A: MYCN Amplified

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

ALK mutation

WT: Wild Type

TMM:Telomere Maintenance mechanism

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive