CHILDHOOD CANCER REPOSITORY

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MYCN Non Amplified

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell LinePhase of Therapy Sample TypeMYCN*ALKTMMTp53p53pO2  
         2%5%20%
COG-N-269PDlymph node2WTTERT +    ✓
COG-N-291PDbone marrow3WTEST    ✓
COG-N-295Dxsolid tumor2F1174LTERT +    ✓
COG-N-298Dxsolid tumor11R1275QTERT +    ✓
COG-N-316Dxbone marrow2 TERT +    ✓
COG-N-323Dxtumor2WTEST    ✓
COG-N-346PDtumor2WTTERT +   ✓ 
COG-N-442hDxleft bone marrow2WTEST   ✓ 
COG-N-443hPDright bone marrow1F1245CTERT +  ✓✓✓
COG-N-469hPDleft bone marrow2F1174LTERT +  ✓✓✓
COG-N-470PD-PMblood2F1174LTERT + F✓✓ 
COG-N-476PDtumor3WTTERT +   ✓✓
COG-N-478PDleft bone marrow3WTTERT +   ✓ 
COG-N-504Dxbone marrow2     ✓✓
COG-N-509hnbDxbone marrow2 EST   ✓ 
COG-N-509hnbDxbone marrow2 EST   ✓ 
COG-N-511h2PDbone marrow2 TERT +  ✓✓ 
COG-N-518Dxbone marrow4 EST NF✓✓✓
COG-N-529PD-PMblood2WTTERT + F✓✓✓
COG-N-532Dxbone marrow2    ✓✓✓
COG-N-534PD-PMblood4F1245CTERT + NF✓✓✓
COG-N-540Dxbone marrow8 TERT +  ✓✓✓
COG-N-544Dxbone marrow8    ✓✓✓
COG-N-548Dxbone marrow2    ✓✓✓
COG-N-549PDtumor2F1174L   ✓✓✓
FelixPD-PMblood2F1245VTERT +R342F ✓✓
FU-NB-2006PD-PMbloodNWTTERT +   ✓✓
N623FLY-hnbPD-PMbloodNF1275QTERT +   ✓ 
LA-N-6PDbone marrowND1091NEST F  ✓
NB-EBc1PD NWT     ✓
SK-N-FIPD NWTALTM246RNF  ✓
SMS-LHNPDsolid tumorN TERT + F  ✓
CHLA-15DxtumorNR1275QTERT + F  ✓
CHLA-16Dxpleural fluidNR1275QTERT +    ✓
CHLA-20PDtumor (neck)NR1275QTERT + F  ✓
CHLA-22PDbone marrowN      ✓
CHLA-42Dxbone marrowNR1275QTERT + F  ✓
CHLA-51PDbone marrowNWT  F  ✓
CHLA-60PD-PMbone marrowNWTTERT + F  ✓
CHLA-61PD-PMperipheral bloodNR1275QTERT + F  ✓
CHLA-70PDbone marrowN      ✓
CHLA-79PDtumorNWTTERT + F  ✓
CHLA-90PDbone marrowNF1245VALTE286KNF  ✓
CHLA-132PDbone marrowN EST    ✓
CHLA-140PDbone marrowNWT     ✓
CHLA-146PDbone marrowN      ✓
CHLA-150PDbone marrowNR1275Q     ✓
CHLA-171PD-PMperiperhal bloodNWTTERT +WTNF  ✓
CHLA-172PDbone marrowNWTTERT +V216LNF  ✓
CHLA-183PDbone marrowN      ✓
COG-N-372hPDbone marrowNWTTERT +   ✓ 
COG-N-500Dxbone marrowN TERT +   ✓✓
COG-N-503hDxbone marrowN     ✓ 
COG-N-504Dxbone marrowN     ✓✓
COG-N-511h2PDbone marrowN TERT +  ✓✓ 
COG-N-529PD-PMbloodNWTTERT + F✓✓✓
COG-N-532Dxbone marrowN    ✓✓✓
COG-N-534PD-PMbloodNF1245CTERT + NF✓✓✓
COG-N-540Dxbone marrowN TERT +  ✓✓✓
COG-N-548Dxbone marrowN    ✓✓✓
COG-N-549PDtumorNF1174L   ✓✓✓
COG-N-562hnbDxtumorN EST  ✓✓✓
COG-N-565PDright bone marrowN    ✓✓✓
COG-N-566DxbloodN    ✓✓✓
COG-N-571Dxbone marrowN     ✓✓
COG-N-572hDxbone marrowN     ✓ 
COG-N-578PDbone marrowN    ✓✓✓
COG-N-579hPDbone marrowN    ✓✓ 
COG-N-587hDxbone marrowN    ✓✓✓
COG-N-597hDxbone marrowN    ✓✓ 
COG-N-598h2Dxbone marrowN    ✓✓ 
COG-N-615PD-PMbloodN TERT +  ✓✓✓
COG-N-616hDxbone marrowN     ✓ 
COG-N-618PDbone marrowNWT   ✓✓✓
COG-N-619PDbone marrowNWT   ✓✓✓
COG-N-651h2Dxbone marrowN TERT +  ✓  
COG-N-652h2Dxbone marrowN       
COG-N-660hnbPD-PMbloodN     ✓

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

2 -MYCN oncogene amplification
N: MYCN Non-Amplified
A: MYCN Amplified

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

ALK mutation

WT: Wild Type

TMM:Telomere Maintenance mechanism

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive