CHILDHOOD CANCER REPOSITORY

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Progressive Disease and Post Mortem Models

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell LinePhase of Therapy Sample TypeMYCN*ALKTMMTp53p53pO2  
         2%5%20%
LA-N-6PDbone marrowND1091NEST F  ✓
NB-EBc1PD NWT     ✓
SK-N-BE(2)PD AWTTERT +C135FNF  ✓
SK-N-FIPD NWTALTM246RNF  ✓
SMS-KANRPDbone marrowAWT  F  ✓
SMS-KCNRPDbone marrowAF1174LTERT + F  ✓
SMS-LHNPDsolid tumorN TERT + F  ✓
CHLA-8PDtumorAWT  F  ✓
CHLA-20PDtumor (neck)NR1275QTERT + F  ✓
CHLA-21PDbone marrowA      ✓
CHLA-22PDbone marrowN      ✓
CHLA-24PDpleural fluidAWTTERT +    ✓
CHLA-28PDbone marrowAF1245C     ✓
CHLA-34PDbone marrowN      ✓
CHLA-41PDtumorAWT     ✓
CHLA-46PDtumorAWT     ✓
CHLA-51PDbone marrowNWT  F  ✓
CHLA-58PDtumor       ✓
CHLA-70PDbone marrowN      ✓
CHLA-72PDperipheral bloodA      ✓
CHLA-79PDtumorNWTTERT + F  ✓
CHLA-81PDtumorA      ✓
CHLA-90PDbone marrowNF1245VALTE286KNF  ✓
CHLA-95PDtumorAR1275Q     ✓
CHLA-102PDtumorA      ✓
CHLA-103PDtumor       ✓
CHLA-108PDbone marrowA      ✓
CHLA-110PDbone marrowA      ✓
CHLA-119PDbone marrowAWTTERT + NF  ✓
CHLA-125PDbone marrowA      ✓
CHLA-127PDtumor       ✓
CHLA-132PDbone marrowN EST    ✓
CHLA-134PDbone marrowAWT  NF  ✓
CHLA-136PDperipheral bloodAWTTERT +WTF  ✓
CHLA-140PDbone marrowNWT     ✓
CHLA-145PDbone marrowAWTTERT +    ✓
CHLA-146PDbone marrowN      ✓
CHLA-150PDbone marrowNR1275Q     ✓
CHLA-161PDbone marrow       ✓
CHLA-172PDbone marrowNWTTERT +V216LNF  ✓
CHLA-183PDbone marrowN      ✓
CHLA-188LPDbone marrowAWT     ✓
CHLA-188RPDbone marrowAWT     ✓
CHLA-189PDperipheral blood       ✓
CHLA-232PD A      ✓
CHLA-247PDbone marrowAWTTERT +    ✓
CHLA-253PDtumorAWT     ✓
COG-N-269PDlymph node2WTTERT +    ✓
COG-N-284PDliver metastasis       ✓
COG-N-289PDsolid tumor160WTTERT +    ✓
COG-N-291PDbone marrow3WTEST    ✓
COG-N-318PDsolid tumor400WTTERT +    ✓
COG-N-321PDbone marrow29 TERT + NF  ✓
COG-N-325PDtumorAWTEST    ✓
COG-N-327PDbone marrow300WTTERT +   ✓✓
COG-N-334PDbone marrow30WTTERT +   ✓✓
COG-N-346PDtumor2WTTERT +   ✓ 
COG-N-372hPDbone marrowNWTTERT +   ✓ 
COG-N-387hPD 152WTEST   ✓ 
COG-N-443hPDright bone marrow1F1245CTERT +  ✓✓✓
COG-N-469hPDleft bone marrow2F1174LTERT +  ✓✓✓
COG-N-473hPDbone marrow150WTTERT +  ✓✓✓
COG-N-475hPDtumor119R1275Q    ✓✓
COG-N-476PDtumor3WTTERT +   ✓✓
COG-N-478PDleft bone marrow3WTTERT +   ✓ 
COG-N-482hPDbone marrowA TERT +  ✓✓ 
COG-N-507hPDbone marrow97     ✓ 
COG-N-508hPDbone marrowA     ✓ 
COG-N-511h2PDbone marrowN TERT +  ✓✓ 
COG-N-512 PDbone marrow210 ALTWT ✓✓✓
COG-N-513PDbone marrowA    ✓✓✓
COG-N-514PDbone marrowA    ✓✓ 
COG-N-515PDbone marrow183 ALTWT ✓✓✓
COG-N-549PDtumorNF1174L   ✓✓✓
COG-N-553PDbone marrowA TERT +  ✓✓✓
COG-N-565PDright bone marrowN    ✓✓✓
COG-N-576h2PDbone marrow     ✓  
COG-N-578PDbone marrowN    ✓✓✓
COG-N-579hPDbone marrowN    ✓✓ 
COG-N-596hPDtumorA    ✓✓ 
COG-N-599PDbone marrowA    ✓✓✓
COG-N-618PDbone marrowNWT   ✓✓✓
COG-N-619PDbone marrowNWT   ✓✓✓
COG-N-621hPDbone marrow     ✓✓ 
COG-N-623PDtumorAWT   ✓✓✓
COG-N-632hPDbone marrow      ✓ 
COG-N-633PDbone marrow     ✓✓✓
COG-N-677hnbPDbone marrow      ✓ 
COG-N-678hPDbone marrow      ✓ 
COG-N-680PDbone marrow     ✓ ✓
FelixPD-PMbloodNF1245VTERT +R342*F ✓✓
FU-NB-2006PD-PMbloodNWTTERT +   ✓✓
N623FLY-hnbPD-PMbloodNF1275QTERT +   ✓ 
CHLA-11PD-PMperipheral bloodAWTTERT + NF  ✓
CHLA-12PD-PMbone marrowAWTTERT + NF  ✓
CHLA-52PD-PMbone marrowAF1174LTERT + N  ✓
CHLA-53PD-PMperipheral bloodAF1174LTERT + NF  ✓
CHLA-60PD-PMbone marrowNWTTERT + F  ✓
CHLA-61PD-PMperipheral bloodNR1275QTERT + F  ✓
CHLA-171PD-PMperiperhal bloodNWTTERT +WTNF  ✓
CHLA-225PD-PMpleural fluidAWTTERT + NF  ✓
COG-N-399PD-PMblood50WTTERT + F ✓✓
COG-N-415PD-PMblood400F1174LTERT +   ✓✓
COG-N-421PD-PMblood34WTTERT + NF   
COG-N-440PD-PMblood250WTTERT + F ✓ 
COG-N-452PD-PMblood62F1174LTERT + F✓✓✓
COG-N-453PD-PMtumor318WTTERT + F✓✓ 
COG-N-470PD-PMblood2F1174LTERT + F✓✓ 
COG-N-471PD-PMblood360WTTERT + NF ✓ 
COG-N-505PD-PMblood96WTTERT + F✓✓✓
COG-N-519PD-PMblood106WTTERT + NF✓✓✓
COG-N-529PD-PMbloodNWTTERT + F✓✓✓
COG-N-534PD-PMbloodNF1245CTERT + NF✓✓✓
COG-N-536hPD-PMbloodAR1275QTERT + NF✓✓ 
COG-N-561PD-PMbloodA F1245ITERT + F✓✓✓
COG-N-564hPD-PMbloodA TERT +  ✓✓ 
COG-N-577PD-PMblood     ✓✓✓
COG-N-615PD-PMbloodN TERT +  ✓✓✓
COG-N-645PD-PMblood       ✓
COG-N-660hnbPD-PMbloodN     ✓ 
COG-N-672PD-PMblood     ✓✓✓
COG-N-685PD-PMblood     ✓✓✓

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

2 -MYCN oncogene amplification
N: MYCN Non-Amplified
A: MYCN Amplified

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

ALK mutation

WT: Wild Type

TMM:Telomere Maintenance mechanism

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive