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Neuroblastoma

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell LinePhase of Therapy Sample TypeMYCN*ALKTMMTp53p53Available Oxygen Conditions
        2%5%20%
FelixPD-PMbloodNF1245VTERT+R342*F ✓✓
FU-NB-2006PD-PMbloodNWTTERT+   ✓✓
LA-N-5Dxbone marrowAR1275QTERT+    ✓
LA-N-6PDbone marrowND1091NEST F  ✓
NB-1643Dx AR1275QTERT+    ✓
NB-Ebc1PD NWT     ✓
SK-N-BE(1)Dx AWTTERT+WTF  ✓
SK-N-BE(2)PD AWTTERT+C135FNF  ✓
SK-N-FIPD NWTALTM246RNF  ✓
SMS-KANDxsolid tumorAWT  F  ✓
SMS-KANRPDbone marrowAWT  F  ✓
SMS-KCNDxsolid tumorAR1275QTERT+ F  ✓
SMS-KCNRPDbone marrowAF1174LTERT+ F  ✓
SMS-LHNPDsolid tumorN TERT+ F  ✓
SMS-MSNDxbone marrow       ✓
SMS-SANDxbone marrowAF1174LTERT+ F  ✓
CHLA-8PD-BMTtumorAWT F  ✓
CHLA-11PD-BMT, PMperipheral bloodAWTTERT+ NF  ✓
CHLA-12PD-BMT, PMbone marrowAWTTERT+ NF  ✓
CHLA-14Dx A TERT+    ✓
CHLA-15DxtumorNR1275QTERT+ F  ✓
CHLA-16Dxpleural fluidNR1275QTERT+    ✓
CHLA-20PDtumor (neck)NR1275QTERT+ F  ✓
CHLA-21PDbone marrowA      ✓
CHLA-22PDbone marrowN      ✓
CHLA-24PDpleural fluidAWTTERT+    ✓
CHLA-27Dxbone marrowAF1174L     ✓
CHLA-28PDbone marrowAF1245C     ✓
CHLA-29Dxbone marrowAWTTERT+    ✓
CHLA-30DxtumorA TERT+    ✓
CHLA-34PDbone marrowN      ✓
CHLA-35Dxbone marrow       ✓
CHLA-41PDtumorAWT     ✓
CHLA-42Dxbone marrowNR1275QTERT+ F  ✓
CHLA-43Dxbone marrow WT     ✓
CHLA-44Dxbone marrow  TERT+    ✓
CHLA-46PDtumorAWT     ✓
CHLA-51PD-BMTbone marrowNWT F  ✓
CHLA-52PD-PMbone marrowAF1174LTERT+ NF  ✓
CHLA-53PD-PMperipheral bloodAF1174LTERT+ NF  ✓
CHLA-58PDtumor       ✓
CHLA-60PD-PMbone marrowNWTTERT+ F  ✓
CHLA-61PD-PMperipheral bloodNR1275QTERT+ F  ✓
CHLA-70PDbone marrowN      ✓
CHLA-72PDperipheral bloodA      ✓
CHLA-78Dxbone marrow       ✓
CHLA-79PD-BMTtumorNWTTERT+ F  ✓
CHLA-81PDtumorA      ✓
CHLA-83Dxbone marrow       ✓
CHLA-84Dxtumor       ✓
CHLA-89Dxtumor       ✓
CHLA-90PD-BMTbone marrowNF1245VALTE286KNF  ✓
CHLA-95PDtumorAR1275Q     ✓
CHLA-100Dxtumor       ✓
CHLA-101Dxbone marrow       ✓
CHLA-102PDtumorA      ✓
CHLA-103PDtumor       ✓
CHLA-105Dxbone marrow       ✓
CHLA-108PDbone marrowA      ✓
CHLA-110PDbone marrowA      ✓
CHLA-119PDbone marrowAWTTERT+ NF  ✓
CHLA-122Dxbone marrowAWTTERT+ F  ✓
CHLA-123Dxperipheral bloodA      ✓
CHLA-125PDbone marrowA      ✓
CHLA-126Dxbone marrow       ✓
CHLA-127PDtumor       ✓
CHLA-132PDbone marrowN EST    ✓
CHLA-134PD-BMTbone marrowAWT  NF  ✓
CHLA-136PD-BMTperipheral bloodAWTTERT+WTF  ✓
CHLA-137Dxtumor       ✓
CHLA-138Dxbone marrow       ✓
CHLA-140PDbone marrowNWTTERT+    ✓
CHLA-142Dxbone marrow       ✓
CHLA-144Dxbone marrowAWTTERT+    ✓
CHLA-145PDbone marrowAAWTTERT+   ✓
CHLA-146PDbone marrowN      ✓
CHLA-150PDbone marrowNR1275Q     ✓
CHLA-151DxtumorAR1275Q     ✓
CHLA-160Dxtumor       ✓
CHLA-161PDbone marrow       ✓
CHLA-171PD-PMperiperhal bloodNWTTERT+WTNF  ✓
CHLA-172PD-BMTbone marrowNWTTERT+V216LNF  ✓
CHLA-183PDbone marrowN      ✓
CHLA-188LPD-BMTbone marrowAWT     ✓
CHLA-188RPD-BMTbone marrowAWT     ✓
CHLA-225PD-PMpleural fluidAWTTERT+ NF  ✓
CHLA-232PD A      ✓
CHLA-247PDbone marrowAWTTERT+    ✓
CHLA-253PDtumorAWT     ✓
COG-N-261Dxtumor34WTTERT+    ✓
COG-N-263Dxtumor48NWTTERT+   ✓
COG-N-265 Dxtumor123WTTERT+    ✓
COG-N-269PDlymph node2WTTERT+    ✓
COG-N-272Dxsolid tumor       ✓
COG-N-276Dxbone marrowAWTTERT+    ✓
COG-N-278Dxsolid tumor26      ✓
COG-N-283Dxsolid tumor88 TERT+    ✓
COG-N-284PDliver metastasis       ✓
COG-N-289PDsolid tumor160WTTERT+    ✓
COG-N-290Dxsolid tumor   TERT+   ✓
COG-N-291PDbone marrow3NWTEST   ✓
COG-N-293Dxsolid tumor56AWTTERT+   ✓
COG-N-294Dxsolid tumor42R1275QTERT+ NF  ✓
COG-N-295Dxsolid tumor2 F1174LTERT+    ✓
COG-N-296Dxbone marrowA      ✓
COG-N-297Dxsolid tumor24WTTERT+    ✓
COG-N-298Dxsolid tumor11R1275QTERT+    ✓
COG-N-299Dxsolid tumor193WTTERT+    ✓
COG-N-302Dxsolid tumor       ✓
COG-N-303Dxsolid tumor52WTTERT+    ✓
COG-N-305Dxsolid tumor133WTTERT+    ✓
COG-N-312Dxbone marrow62 TERT+    ✓
COG-N-316Dxbone marrow2TERT+     ✓
COG-N-318PDsolid tumor400WTTERT+    ✓
COG-N-321PDbone marrow29 TERT+ NF  ✓
COG-N-322Dxsolid tumor323WTTERT+    ✓
COG-N-323Dxtumor2WTEST    ✓
COG-N-324Dxbone marrow61WTTERT+    ✓
COG-N-325PDtumorAWTEST    ✓
COG-N-327PDbone marrow300WTTERT+   ✓✓
COG-N-328hDxtumor130WTTERT+   ✓ 
COG-N-331Dxbone marrow85WTTERT+    ✓
COG-N-333Dxbone marrow144F1174LTERT+    ✓
COG-N-334PDbone marrow30WTTERT+   ✓✓
COG-N-346PDtumor2WTTERT+   ✓ 
COG-N-347Dxbone marrow248WTTERT+    ✓
COG-N-349Dxbone marrow90WTTERT+   ✓✓
COG-N-353Dxbone marrow38WTTERT+   ✓✓
COG-N-354Dxbone marrow66 TERT+   ✓✓
COG-N-367Dxbone marrow22R1275QTERT+   ✓✓
COG-N-372hPDbone marrowNWTTERT+   ✓ 
COG-N-373Dxbone marrow78WTTERT+    ✓
COG-N-387hPD 152WTEST   ✓ 
COG-N-399PD-PMblood50WTTERT+ F ✓✓
COG-N-415PD-PMblood400F1174LTERT+   ✓✓
COG-N-421PD-PMblood34WTTERT+ NF   
COG-N-440PD-PMblood250WTTERT+ F ✓ 
COG-N-442hDxleft bone marrow2WTEST   ✓ 
COG-N-443hPDright bone marrow1F1245CTERT+  ✓✓✓
COG-N-445Dxbone marrow117WTTERT+  ✓✓✓
COG-N-452PD-PMblood62F1174LTERT+ F✓✓✓
COG-N-453PD-PMtumor318WTTERT+ F✓✓ 
COG-N-462hDxright bone marrowAWTTERT+  ✓  
COG-N-463h2Dxleft bone marrow277WTTERT+  ✓✓ 
COG-N-469hPDleft bone marrow2F1174LTERT+  ✓✓✓
COG-N-470PD-PMblood2F1174LTERT+ F✓✓ 
COG-N-471PD-PMblood360WTTERT+ NF ✓* 
COG-N-473hPDbone marrow150WTTERT+  ✓✓✓
COG-N-474Dxbone marrow338F1174LTERT+   ✓ 
COG-N-475hPDtumor119R1275Q    ✓✓
COG-N-476PD-BMTtumor3WTTERT+   ✓✓
COG-N-478PDleft bone marrow3WTTERT+   ✓ 
COG-N-480h2Dxright bone marrow42WTTERT+  ✓  
COG-N-482hPDbone marrowA TERT+  ✓✓ 
COG-N-485hDxbone marrow36 TERT+  ✓✓ 
COG-N-490hDxbone marrow208WTTERT+   ✓ 
COG-N-491hDxperipheral blood370WTTERT+  ✓✓ 
COG-N-496Dxbone marrow74WT   ✓✓✓
COG-N-497Dxbone marrow40 TERT+  ✓✓✓
COG-N-500Dxbone marrowN TERT+    ✓
COG-N-503hDxbone marrowN     ✓ 
COG-N-504Dxbone marrow2      ✓
COG-N-505PD-PMblood96WTTERT+ F✓✓✓
COG-N-507hPDbone marrow97     ✓ 
COG-N-508hPDbone marrow44     ✓ 
COG-N-509hnbDxbone marrow2 EST   ✓* 
COG-N-511h2PDbone marrow2 TERT+  ✓  
COG-N-512 PDbone marrow210 ALTWT ✓ ✓
COG-N-513PDbone marrow132    ✓✓✓
COG-N-514PDbone marrow324     ✓✓
COG-N-515PDbone marrow183 ALTWT ✓✓✓
COG-N-518Dxbone marrow4 EST NF✓✓✓
COG-N-519PD-PMblood106WTTERT+ NF✓✓✓
COG-N-521Dxbone marrow      ✓ 
COG-N-522hDxbone marrow252     ✓ 
COG-N-523hDxbone marrow      ✓ 
COG-N-524hDxbone marrow      ✓ 
COG-N-527hDxbone marrow     ✓✓ 
COG-N-529PD-PMblood2WTTERT+ F✓✓✓
COG-N-531hDxbone marrowA      ✓ 
COG-N-532Dxbone marrow2    ✓✓✓
COG-N-534PD-PMblood4F1245CTERT+ NF ✓✓
COG-N-536hPD-PMblood165R1275QTERT+ NF✓✓ 
COG-N-539Dxtumor87     ✓✓
COG-N-540Dxbone marrow8    ✓✓✓
COG-N-542hDxbone marrow134     ✓ 
COG-N-543hDxbone marrow392    ✓✓ 
COG-N-544Dxbone marrow8   ✓✓✓
COG-N-546hDxbone marrowA    ✓✓ 
COG-N-548Dxbone marrow2    ✓✓✓
COG-N-549PDtumor2F1174L   ✓✓✓
COG-N-550hDxbone marrow165    ✓✓ 
COG-N-552hDXbone marrow172    ✓✓ 
COG-N-553PDbone marrow175    ✓✓✓
COG-N-554Dxbone marrow59    ✓✓✓
COG-N-555hDxbone marrow250     ✓ 
COG-N-556Dxbone marrowA    ✓✓ 
COG-N-557Dxbone marrowAF1245LTERT+  ✓✓✓
COG-N-558hDxtumorA    ✓✓ 
COG-N-561PD-PMbloodA F1245ITERT+ F✓✓✓
COG-N-562 DxtumorN TERT+  ✓✓✓
COG-N-563Dxbone marrowA    ✓✓✓
COG-N-564hPD-PMbloodA TERT+  ✓✓ 
COG-N-565PDright bone marrowN    ✓✓✓
COG-N-566DxbloodN    ✓ ✓
COG-N-569hnbDxbone marrow  ALTWT  ✓* 
COG-N-570hDxbloodA    ✓✓ 
COG-N-571Dxbone marrowN     ✓✓
COG-N-572hDxbone marrowN     ✓ 
COG-N-573Dxbone marrowAWTTERT+  ✓✓✓
COG-N-574Dxbone marrowA    ✓✓✓
COG-N-575Dxbone marrowA    ✓✓✓
COG-N-576h2PDbone marrow     ✓  
COG-N-577PD-PMblood     ✓✓✓
COG-N-578PDbone marrowN    ✓✓✓
COG-N-579hPDbone marrowN    ✓✓ 
COG-N-581hDxbone marrowA    ✓✓ 
COG-N-582hDxbone marrowA    ✓✓ 
COG-N-585Dxbone marrowA    ✓✓✓
COG-N-586Dxbone marrowA    ✓✓✓
COG-N-587hDxbone marrowN    ✓✓✓
COG-N-590DxtumorAWTTERT+   ✓✓
COG-N-591Dxbone marrowA    ✓✓✓
COG-N-592Dxbone marrowA    ✓✓✓
COG-N-596hPDtumorA    ✓✓ 
COG-N-597hDxbone marrowN    ✓✓ 
COG-N-598h2Dxbone marrowN    ✓*  
COG-N-599PDbone marrowA    ✓✓✓
COG-N-600Dxbone marrowA    ✓✓✓
COG-N-601h2Dxbone marrowA    ✓  
COG-N-602Dxbone marrow      ✓✓
COG-N-603DxtumorAWTTERT+  ✓✓✓
COG-N-614Dxbone marrow     ✓✓✓
COG-N-615PD-PMbloodN TERT+  ✓✓ 
COG-N-616hDxbone marrowN     ✓ 
COG-N-617hDxbone marrow     ✓✓ 
COG-N-618PD-Post XRTbone marrowNWT   ✓✓✓
COG-N-619PD-Post XRTbone marrowNWT   ✓✓✓
COG-N-621hPDbone marrow     ✓✓ 
COG-N-623PDtumorAWT   ✓✓✓
COG-N-626hDxbone marrow     ✓✓ 
COG-N-627hDxtumorA    ✓✓✓
COG-N-628Dxbone marrowAWT   ✓✓✓
COG-N-632hPDbone marrow      ✓ 
COG-N-633PDbone marrow     ✓✓✓
COG-N-635hDxbone marrow     ✓✓ 
COG-N-636DxtumorAWT   ✓✓✓
COG-N-637Dxbone marrow     ✓✓✓
COG-N-638hDxbone marrow     ✓✓ 
COG-N-639hDxbone marrow     ✓✓ 
COG-N-640hDxbone marrow     ✓✓ 
COG-N-645PD-PMblood     ✓✓✓
COG-N-646Dxbone marrow     ✓✓✓
COG-N-647Dxbone marrow     ✓✓✓
COG-N-651hDxbone marrowN   ✓✓ 
COG-N-652h2Dxbone marrowN    ✓  
COG-N-654hDxbone marrow      ✓ 
COG-N-660hnbPD-PMbloodN     ✓* 
COG-N-662hDxbone marrow      ✓ 
COG-N-663h2Dxbone marrow     ✓  
COG-N-667hDxbone marrow      ✓ 
COG-N-671h        ✓ 
COG-N-672PD-PMblood     ✓✓✓
COG-N-675Dxbone marrow     ✓✓✓
COG-N-677hnbPDbone marrow      ✓* 
COG-N-678hPDbone marrow      ✓ 
COG-N-679Dxbone marrow     ✓✓✓
COG-N-680PDbone marrow     ✓ ✓
COG-N-682Dxbone marrow  TERT+  ✓✓✓
COG-N-683Dxbone marrow     ✓✓✓
COG-N-685PD-PMblood     ✓✓ 
COG-N-696hDxbone marrow      ✓ 
COG-N-697hDxtumor     ✓✓ 
COG-N-698Dxtumor      ✓✓
COG-N-700Dxtumor  ALT  ✓✓✓
COG-N-701Dxbone marrow      ✓✓

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

2 -MYCN oncogene amplification
N: MYCN Non-Amplified
A: MYCN Amplified

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

ALK mutation

WT: Wild Type

TMM:Telomere Maintenance mechanism

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERTTERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive