Patient-Derived Xenografts (PDX)

The Childhood Cancer Repository has patient-derived xenografts (PDXs) established from neuroblastoma, Wilms tumor, Ewings sarcoma, rhabdomyosarcoma, lymphoma, and acute lymphoblastic leukemia. These PDX models are available for distribution to investigators. However, as generation and banking of PDXs is very labor intensive it is important that requests be limited to only those PDX models that can be used in the next year by any laboratory.

For many of the PDXs we have available or in progress whole exome sequencing and RNA sequencing data. Once those data are able to be made publicly available they will placed into online databases and the links included on this website. Investigators seeking PDXs with a particular molecular characteristic prior to those data being available online are encouraged to contact the repository so that we can help investigators identify models that best suit their needs. The same is true for any contemplated use of the PDX models, the repository staff welcomes inquires, we are here to help you find and use the optimal models for your studies.

We are working on developing a bank of DNA, RNA, and tissue from PDX models that can enable screening for features by investigators outside of the repository and beyond those data already obtained on the repository models.

To view a complete PDX description (origin, growth conditions, pictures, etc.), click on the PDX name to open a pdf data sheet to view and/or download.

Please visit the CCcells.org website frequently, as data is continually being updated and PDXs are added.

Any investigator who has need of pediatric cancer PDX models should not hesitate to contact us.